Article
Inhibition of pannexin-1 does not restore electrolyte balance in precystic Pkd1 knockout mice.
Physiological reports - 1 Apr 2024
van Megen Wouter H, van Houtert Teun J, Bos Caro, Peters Dorien J M, de Baaij Jeroen H F, Hoenderop Joost G J
Abstract excerpt
Mutations in PKD1 and PKD2 cause autosomal dominant polycystic kidney disease (ADPKD), which is characterized by the formation of fluid-filled cysts in the kidney. In a subset of ADPKD patients, reduced blood calcium (Ca2+) and magnesium (Mg2+) concentrations are observed. As cystic fluid contains increased ATP concentrations and purinergic signaling reduces electrolyte reabsorption, we hypothesized that...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.