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Article

Inactivation of Pkd1 in principal cells causes a more severe cystic kidney disease than in intercalated cells.

Kidney international - 1 Mar 2009

Raphael Kalani L, Strait Kevin A, Stricklett Peter K, Miller R Lance, Nelson Raoul D, Piontek Klaus B, Germino Gregory G, Kohan Donald E

Abstract excerpt

Renal cysts in autosomal dominant polycystic kidney disease arise from cells throughout the nephron, but there is an uncertainty as to whether both the intercalated cells (ICs) and principal cells (PCs) within the collecting duct give rise to cysts. To determine this, we crossed mice containing l...

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Identifiers

PMID: 19145237
DOI: 10.1038/ki.2008.659
PMCID: PMC3879111

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19145237-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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