Deficiency of polycystic kidney disease-1 gene (PKD1) expression increases A(3) adenosine receptors in human renal cells: implications for cAMP-dependent signalling and proliferation of PKD1-mutated cystic cells.

doi:10.1016/j.bbadis.2009.03.001

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Deficiency of polycystic kidney disease-1 gene (PKD1) expression increases A(3) adenosine receptors in human renal cells: implications for cAMP-dependent signalling and proliferation of PKD1-mutated cystic cells.

Biochimica et biophysica acta - 1 Jun 2009

Aguiari Gianluca, Varani Katia, Bogo Marco, Mangolini Alessandra, Vincenzi Fabrizio, Durante Chiara, Gessi Stefania, Sacchetto Valeria, Catizone Luigi, Harris Peter, Rizzuto Rosario, Borea Pier Andrea, Del Senno Laura

Abstract excerpt

Cyst growth and expansion in autosomal dominant polycystic kidney disease (ADPKD) has been attributed to numerous factors, including ATP, cAMP and adenosine signalling. Although the role of ATP and cAMP has been widely investigated in PKD1-deficient cells, no information is currently available on adenosine-mediated signalling. Here we investigate for the first time the impact of abnormalities of polycystin-1...

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Deficiency of polycystic kidney disease-1 gene (PKD1) expression increases A(3) adenosine receptors in human renal cells: implications for cAMP-dependent signalling and proliferation of PKD1-mutated cystic cells.

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