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Article

Gender-Dependent Phenotype in Polycystic Kidney Disease Is Determined by Differential Intracellular Ca2+ Signals.

International journal of molecular sciences - 2 Jun 2021

Talbi Khaoula, Cabrita Inês, Schreiber Rainer, Kunzelmann Karl

Abstract excerpt

Autosomal dominant polycystic kidney disease (ADPKD) is caused by loss of function of PKD1 (polycystin 1) or PKD2 (polycystin 2). The Ca2+-activated Cl- channel TMEM16A has a central role in ADPKD. Expression and function of TMEM16A is upregulated in ADPKD which causes enhanced intracellular Ca2+ signaling, cell proliferation, and ion secretion. We analyzed kidneys from Pkd1 knockout mice and found a more...

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Identifiers

PMID: 34199520
DOI: 10.3390/ijms22116019
PMCID: PMC8199720

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