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Article

Inhibition of the P2X7 receptor reduces cystogenesis in PKD.

Journal of the American Society of Nephrology : JASN - 1 Sept 2011

Chang Ming-Yang, Lu Jenn-Kan, Tian Ya-Chung, Chen Yung-Chang, Hung Cheng-Chieh, Huang Yi-Hui, Chen Yau-Hung, Wu Mai-Szu, Yang Chih-Wei, Cheng Yi-Chuan

Abstract excerpt

The P2X7 receptor participates in purinergic signaling, which may promote the progression of ADPKD. We examined the effects of a P2X7 receptor antagonist and a P2X7 receptor agonist on cyst development in a zebrafish model of polycystic kidney disease in which we knocked down pkd2 by morpholinos. We used live wt-1b pronephric-specific GFP-expressing zebrafish embryos to directly observe changes in the pronephros....

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Identifiers

PMID: 21636640
DOI: 10.1681/ASN.2010070728
PMCID: PMC3171940

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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