Article
Decreased renal organic anion secretion and plasma accumulation of endogenous organic anions in OAT1 knock-out mice.
The Journal of biological chemistry - 24 Feb 2006
Eraly Satish A, Vallon Volker, Vaughn Duke A, Gangoiti Jon A, Richter Kerstin, Nagle Megha, Monte Julio C, Rieg Timo, Truong David M, Long Jeffrey M, Barshop Bruce A, Kaler Gregory, Nigam Sanjay K
Abstract excerpt
The "classical" organic anion secretory pathway of the renal proximal tubule is critical for the renal excretion of the prototypic organic anion, para-aminohippurate, as well as of a large number of commonly prescribed drugs among other significant substrates. Organic anion transporter 1 (OAT1), originally identified as NKT (Lopez-Nieto, C. E., You, G., Bush, K. T., Barros, E. J. G., Beier, D. R., and Nigam, S....
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