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Article

Cyst formation following disruption of intracellular calcium signaling.

Proceedings of the National Academy of Sciences of the United States of America - 30 Sept 2014

Kuo Ivana Y, DesRochers Teresa M, Kimmerling Erica P, Nguyen Lily, Ehrlich Barbara E, Kaplan David L

Abstract excerpt

Mutations in polycystin 1 and 2 (PC1 and PC2) cause the common genetic kidney disorder autosomal dominant polycystic kidney disease (ADPKD). It is unknown how these mutations result in renal cysts, but dysregulation of calcium (Ca(2+)) signaling is a known consequence of PC2 mutations. PC2 functi...

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Identifiers

PMID: 25228769
DOI: 10.1073/pnas.1412323111
PMCID: PMC4191767

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25228769-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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