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Article

Knockout ofP2rx7purinergic receptor attenuates cyst growth in a rat model of ARPKD

21 Oct 2019

Abstract excerpt

The severity of polycystic kidney diseases (PKD) depends on the counterbalancing of genetic predisposition and environmental factors exerting permissive or protective influence on cyst development. One poorly characterized phenomenon in the cystic epithelium is abnormal purinergic signaling. Earlier experimental studies revealed the high importance of the ionotropic P2X receptors (particularly, P2X7) in the...

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PMID: 31630543
DOI: 10.1152/ajprenal.00395.2019

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