Article
Sodium-dependent phosphate cotransporters: lessons from gene knockout and mutation studies.
Journal of pharmaceutical sciences - 1 Sept 2011
Miyamoto Ken-ichi, Haito-Sugino Sakiko, Kuwahara Shoji, Ohi Akiko, Nomura Kengo, Ito Mikiko, Kuwahata Masashi, Kido Shinsuke, Tatsumi Sawako, Kaneko Ichiro, Segawa Hiroko
Abstract excerpt
Inorganic phosphate (Pi) is an essential physiological compound, highlighted by the syndromes caused by hypo or hyperphosphatemic states. Hyperphosphatemia is associated with ectopic calcification, cardiovascular disease, and increased mortality in patients with chronic kidney disease (CKD). As phosphate control is not efficient with diet or dialysis, oral Pi binders are used in over 90% of patients with renal...
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