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Article

Generation and phenotypic characterization of Pde1a mutant mice.

PloS one - 1 Jan 2017

Wang Xiaofang, Yamada Satsuki, LaRiviere Wells B, Ye Hong, Bakeberg Jason L, Irazabal María V, Chebib Fouad T, van Deursen Jan, Harris Peter C, Sussman Caroline R, Behfar Atta, Ward Christopher J, Torres Vicente E

Abstract excerpt

It has been proposed that a reduction in intracellular calcium causes an increase in intracellular cAMP and PKA activity through stimulation of calcium inhibitable adenylyl cyclase 6 and inhibition of phosphodiesterase 1 (PDE1), the main enzymes generating and degrading cAMP in the distal nephron and collecting duct, thus contributing to the development and progression of autosomal dominant polycystic kidney...

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Source

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Identifiers

PMID: 28750036
DOI: 10.1371/journal.pone.0181087
PMCID: PMC5531505

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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