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Immune System Deficiencies Do Not Alter SARS-CoV-2 Evolutionary Rate but Favour the Emergence of Mutations by Extending Viral Persistence.

Viruses - 13 Mar 2024

Manuto Laura, Bado Martina, Cola Marco, Vanzo Elena, Antonello Maria, Mazzotti Giorgia, Pacenti Monia, Cordioli Giampaolo, Sasset Lolita, Cattelan Anna Maria, Toppo Stefano, Lavezzo Enrico

Abstract excerpt

During the COVID-19 pandemic, immunosuppressed patients showed prolonged SARS-CoV-2 infections, with several studies reporting the accumulation of mutations in the viral genome. The weakened immune system present in these individuals, along with the effect of antiviral therapies, are thought to create a favourable environment for intra-host viral evolution and have been linked to the emergence of new viral...

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PMID: 38543811
DOI: 10.3390/v16030447
PMCID: PMC10974344

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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