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Article

SARS-CoV-2 intra-host evolution during prolonged infection in an immunocompromised patient.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 1 Sept 2022

Quaranta Erika Giorgia, Fusaro Alice, Giussani Edoardo, D'Amico Valeria, Varotto Maria, Pagliari Matteo, Giordani Maria Teresa, Zoppelletto Maira, Merola Francesca, Antico Antonio, Stefanelli Paola, Terregino Calogero, Monne Isabella

Abstract excerpt

OBJECTIVES: Intra-host SARS-CoV-2 evolution during chronic infection in immunocompromised hosts has been suggested as being the possible trigger of the emergence of new variants. METHODS: Using a deep sequencing approach, we investigated the SARS-CoV-2 intra-host genetic evolution in a patient with HIV over a period of 109 days. RESULTS: Sequencing of nasopharyngeal swabs at three time points demonstrated dynamic...

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Identifiers

PMID: 35724829
DOI: 10.1016/j.ijid.2022.06.023
PMCID: PMC9212919

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