Article
Cumulative SARS-CoV-2 mutations and corresponding changes in immunity in an immunocompromised patient indicate viral evolution within the host.
Nature communications - 10 May 2022
Sonnleitner Sissy Therese, Prelog Martina, Sonnleitner Stefanie, Hinterbichler Eva, Halbfurter Hannah, Kopecky Dominik B C, Almanzar Giovanni, Koblmüller Stephan, Sturmbauer Christian, Feist Leonard, Horres Ralf, Posch Wilfried, Walder Gernot
Abstract excerpt
Different scenarios explaining the emergence of novel variants of concern (VOC) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been reported, including their evolution in scarcely monitored populations, in animals as alternative hosts, or in immunocompromised individuals. Here we report SARS-CoV-2 immune escape mutations over a period of seven months in an immunocompromised patient with...
Topics
- Animals
- COVID-19
- Immunocompromised Host
- Mutation
- SARS-CoV-2
- Spike Glycoprotein, Coronavirus