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Case reports of persistent SARS-CoV-2 infection outline within-host viral evolution in immunocompromised patients.

Virology journal - 3 Sept 2024

Ruotolo Luca, Silenzi Silvia, Mola Beatrice, Ortalli Margherita, Lazzarotto Tiziana, Rossini Giada

Abstract excerpt

BACKGROUND: SARS-CoV-2 is responsible for the ongoing global pandemic, and the continuous emergence of novel variants threatens fragile populations, such as immunocompromised patients. This subgroup of patients seems to be seriously affected by intrahost viral changes, as the pathogens, which are keen to cause replication inefficiency, affect the impaired immune system, preventing efficient clearance of the...

Topics

Humans
COVID-19
SARS-CoV-2
Middle Aged
Immunocompromised Host
High-Throughput Nucleotide Sequencing
Genome, Viral
Male
Mutation
Evolution, Molecular
Nasopharynx

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39227954
DOI: 10.1186/s12985-024-02483-y
PMCID: PMC11373299

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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