Article

Combined Effects of Severe Immunocompromise and Prolonged Virus Shedding on Within-Host SARS-CoV-2 Evolution in COVID-19

2026-04-17

Abstract excerpt

<h4>Background</h4> Prolonged SARS-CoV-2 infection in immunocompromised individuals may accelerate virus evolution within the host, raising concerns about the virus evading immunity, developing resistance, and forming novel variants of concern. However, the determinants and public health implications of within-host viral evolution in this population remain incompletely understood. <h4>Methods</h4> We performed l...

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Literature Corpus work: f08b1dd1-7bf2-5e82-a9e2-2576ef49e511
DOI: 10.64898/2026.04.14.26350918

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