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Article

SARS-CoV-2: The Interplay Between Evolution and Host Immunity.

Annual review of immunology - 1 Apr 2025

Case James Brett, Jain Shilpi, Suthar Mehul S, Diamond Michael S

Abstract excerpt

The persistence of SARS-CoV-2 infections at a global level reflects the repeated emergence of variant strains encoding unique constellations of mutations. These variants have been generated principally because of a dynamic host immune landscape, the countermeasures deployed to combat disease, and selection for enhanced infection of the upper airway and respiratory transmission. The resulting viral diversity...

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Identifiers

PMID: 39705164
DOI: 10.1146/annurev-immunol-083122-043054
PMCID: PMC13456083

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