Article

Structural recognition and stabilization of tyrosine hydroxylase by the J-domain protein DNAJC12

2023-12-06

Abstract excerpt

<title>Abstract</title> <p>Pathogenic variants of the J-domain protein and Hsp70 cochaperone DNAJC12 cause parkinsonism, which is associated with a defective interaction of DNAJC12 with tyrosine hydroxylase (TH), the rate-limiting enzyme in dopamine (DA) biosynthesis. Here, we report the characterization of TH:DNAJC12 complex formation, showing that DNAJC12 binding stabilizes TH and delays its time-dependent aggr...

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Literature Corpus work: bc707f21-8626-548c-bd95-43369560eaa9
DOI: 10.21203/rs.3.rs-3621320/v1

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