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Article

Versatile members of the DNAJ family show Hsp70 dependent anti-aggregation activity on RING1 mutant parkin C289G.

Scientific reports - 7 Oct 2016

Kakkar Vaishali, Kuiper E F Elsiena, Pandey Abhinav, Braakman Ineke, Kampinga Harm H

Abstract excerpt

Parkinson's disease is one of the most common neurodegenerative disorders and several mutations in different genes have been identified to contribute to the disease. A loss of function parkin RING1 domain mutant (C289G) is associated with autosomal-recessive juvenile-onset Parkinsonism (AR-JP) and displays altered solubility and sequesters into aggregates. Single overexpression of almost each individual member of...

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Source

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Identifiers

PMID: 27713507
DOI: 10.1038/srep34830
PMCID: PMC5054386

Genes

DNAJB6
DNAJB8
RING1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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