Article

Tertiary structure and conformational dynamics of the anti-amyloidogenic chaperone DNAJB6b at atomistic resolution

2023-06-15

Abstract excerpt

DNAJB6b is a molecular chaperone of the heat shock protein network, shown to play a crucial role in preventing aggregation of several disease-related intrinsically disordered proteins. Despite its importance in maintaining cellular homeostasis, the structure-functional relationship of DNAJB6b is not yet known. Using homology modeling and microsecond-long all-atom molecular dynamics (MD) simulations, we show that m...

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Literature Corpus work: dc834e32-5f97-5152-b40e-fb9dc5545f96
DOI: 10.1101/2023.06.15.545060

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