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Article

FUS regulates genes coding for RNA-binding proteins in neurons by binding to their highly conserved introns

6 Feb 2013

Abstract excerpt

Dominant mutations and mislocalization or aggregation of Fused in Sarcoma (FUS), an RNA-binding protein (RBP), cause neuronal degeneration in Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Lobar Degeneration (FTLD), two incurable neurological diseases. However, the function of FUS in neurons is not well understood. To uncover the impact of FUS in the neuronal transcriptome, we used high-throughput...

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PMID: 23389473
DOI: 10.1261/rna.037804.112

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FUS regulates genes coding for RNA-binding proteins in neurons by binding to their highly conserved intronsPMID 23389473Read ↗

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Loss of fused in sarcoma (FUS) promotes pathological Tau splicing.Semantic proximity Read ↗

<i>FUS</i> ALS-causative mutations impact <i>FUS</i> autoregulation and the processing of RNA-binding proteins through intron retentionSemantic proximity Read ↗

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Synaptic accumulation of FUS triggers age-dependent misregulation of inhibitory synapses in ALS-FUS miceSemantic proximity Read ↗

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