Article
ALS-FUS mutations cause abnormal PARylation and histone H1.2 interaction, leading to pathological changes.
Cell reports - 27 Aug 2024
Alirzayeva Hafiza, Loureiro Rute, Koyuncu Seda, Hommen Franziska, Nabawi Yara, Zhang William Hongyu, Dao Thien T P, Wehrmann Markus, Lee Hyun Ju, Vilchez David
Abstract excerpt
The majority of severe early-onset and juvenile cases of amyotrophic lateral sclerosis (ALS) are caused by mutations in the FUS gene, resulting in rapid disease progression. Mutant FUS accumulates within stress granules (SGs), thereby affecting the dynamics of these ribonucleoprotein complexes. Here, we define the interactome of the severe mutant FUSP525L variant in human induced pluripotent stem cell...
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