Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A genome-wide association study of neutrophil count in individuals associated to an African continental ancestry group facilitates studies of malaria pathogenesis.

Human genomics - 15 Mar 2024

Constantinescu Andrei-Emil, Hughes David A, Bull Caroline J, Fleming Kathryn, Mitchell Ruth E, Zheng Jie, Kar Siddhartha, Timpson Nicholas J, Amulic Borko, Vincent Emma E

Abstract excerpt

BACKGROUND: 'Benign ethnic neutropenia' (BEN) is a heritable condition characterized by lower neutrophil counts, predominantly observed in individuals of African ancestry, and the genetic basis of BEN remains a subject of extensive research. In this study, we aimed to dissect the genetic architecture underlying neutrophil count variation through a linear-mixed model genome-wide association study (GWAS) in a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Black People
Share to Gene Frequency

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Malaria

Share to Neutrophils

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 38491524
DOI: 10.1186/s40246-024-00585-w
PMCID: PMC10941368

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A genome-wide association study of neutrophil count in individuals associated to an African continental ancestry group facilitates studies of malaria pathogenesis.PMID 38491524Read ↗

Investigating a causal role for neutrophil count on<i>P. falciparum</i>severe malaria: a Mendelian Randomization studySemantic proximity Read ↗

A comprehensive phenome wide analysis of the role of neutrophils in health and diseaseSemantic proximity Read ↗

Functional analysis of genome-wide dataset from 17000 individuals identifies multiple candidate malaria resistance genes enriched in malaria pathogenic pathwaysSemantic proximity Read ↗

Genetics of Malaria Inflammatory Responses: A Pathogenesis PerspectiveSemantic proximity Read ↗

Insights into malaria susceptibility using genome-wide data on 17,000 individuals from Africa, Asia and Oceania.Semantic proximity Read ↗

2SNP heritability and effects of genetic variants for neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio.Semantic proximity Read ↗

New insights into malaria susceptibility from the genomes of 17,000 individuals from Africa, Asia, and OceaniaSemantic proximity Read ↗

Genome-wide association studies of severe P. falciparum malaria susceptibility: progress, pitfalls and prospectsSemantic proximity Read ↗

Genome-wide association study indicates two novel resistance loci for severe malaria.Semantic proximity Read ↗

Large-scale genotyping and meta-analysis of <i>PIEZO1</i> short tandem repeat alleles suggest a modest association with malaria susceptibilitySemantic proximity Read ↗

Genetic variation associated with circulating monocyte count in the eMERGE NetworkSemantic proximity Read ↗

Sequence variants in three loci influence monocyte counts and erythrocyte volume.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.