Genomic analysis of cellular hierarchy in acute myeloid leukemia using ultrasensitive LC-FACSeq.

doi:10.1038/s41375-021-01295-1

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Genomic analysis of cellular hierarchy in acute myeloid leukemia using ultrasensitive LC-FACSeq.

Leukemia - 1 Dec 2021

Saygin Caner, Hu Eileen, Zhang Pu, Sher Steven, Lozanski Arletta, Doong Tzyy-Jye, Nicolet Deedra, Orwick Shelley, Labanowska Jadwiga, Skinner Jordan N, Cempre Casey, Kauffman Tierney, Goettl Virginia M, Heerema Nyla A, Abruzzo Lynne, Miller Cecelia, Lapalombella Rosa, Behbehani Gregory, Mims Alice S, Larkin Karilyn, Grieselhuber Nicole, Walker Alison, Bhatnagar Bhavana, Bloomfield Clara D, Byrd John C, Lozanski Gerard, Blachly James S

Abstract excerpt

Hematopoiesis is hierarchical, and it has been postulated that acute myeloid leukemia (AML) is organized similarly with leukemia stem cells (LSCs) residing at the apex. Limited cells acquired by fluorescence activated cell sorting in tandem with targeted amplicon-based sequencing (LC-FACSeq) enables identification of mutations in small subpopulations of cells, such as LSCs. Leveraging this, we studied clonal...

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PMID: 34021247
DOI: 10.1038/s41375-021-01295-1
PMCID: PMC8606012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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