Article
Genetic variation of FcγRIIa induces higher uptake of Leishmania infantum and modulates cytokine production by adherent mononuclear cells in vitro.
Frontiers in immunology - 1 Jan 2024
Catarino Jonatas da Silva, de Oliveira Rafael Faria, Silva Marcos Vinicius, Sales-Campos Helioswilton, de Vito Fernanda Bernadelli, da Silva Djalma Alexandre Alves, Naves Lucila Langoni, Oliveira Carlo José Freire, Rodrigues Denise Bertulucci Rocha, Rodrigues Virmondes
Abstract excerpt
Introduction: Single nucleotide variations (SNVs) are specific genetic variations that commonly occur in a population and often do not manifest phenotypically. However, depending on their location and the type of nucleotide exchanged, an SNV can alter or inhibit the function of the gene in which it occurs. Immunoglobulin G (IgG) receptor genes have exhibited several polymorphisms, including rs1801274, which is...
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