Novel Human FCGR1A Variants Affect CD64 Functions and Are Risk Factors for Sarcoidosis.

doi:10.3389/fimmu.2022.841099

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Article

Novel Human FCGR1A Variants Affect CD64 Functions and Are Risk Factors for Sarcoidosis.

Frontiers in immunology - 1 Jan 2022

Wu Jianming, Li Yunfang, Rendahl Aaron, Bhargava Maneesh

Abstract excerpt

CD64 (or FcγRIA) is the sole functional high affinity IgG Fc receptor coded by FCGR1A gene in humans. The FCGR1A genetics has not been comprehensively investigated and effects of human FCGR1A variants on immune functions remain unknown. In the current study, we identified three novel FCGR1A variants including the single nucleotide variant (SNV) rs1848781 (c.-131) in the proximal FCGR1A gene promoter region, the...

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PMID: 35371020
DOI: 10.3389/fimmu.2022.841099
PMCID: PMC8968912

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