Article
Single Nucleotide Polymorphisms of the High Affinity IgG Receptor FcγRI Reduce Immune Complex Binding and Downstream Effector Functions.
Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 2017
Brandsma Arianne M, Ten Broeke Toine, van Dueren den Hollander Evelien, Caniels Thomas G, Kardol-Hoefnagel Tineke, Kuball Jürgen, Leusen Jeanette H W
Abstract excerpt
Binding of IgG Abs to FcγRs on immune cells induces FcγR cross-linking that leads to cellular effector functions, such as phagocytosis, Ab-dependent cellular cytotoxicity, and cytokine release. However, polymorphisms in low affinity FcγRs have been associated with altered avidity toward IgG, thereby substantially impacting clinical outcomes of multimodular therapy when targeting cancer or autoimmune diseases with...
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