Effects of an FcγRIIA polymorphism on leukocyte gene expression and cytokine responses to anti-CD3 and anti-CD28 antibodies.

doi:10.1038/s41435-018-0038-8

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Article

Effects of an FcγRIIA polymorphism on leukocyte gene expression and cytokine responses to anti-CD3 and anti-CD28 antibodies.

Genes and immunity - 1 Jul 2019

Stein Michelle M, Hrusch Cara L, Sperling Anne I, Ober Carole

Abstract excerpt

The low affinity Fcγ receptor, FcγRIIA, harbors a common missense mutation, rs1801274 (G>A, Arg131His) that modifies binding affinity to human IgG2 and mouse IgG1 antibodies and is associated with increased risk of autoimmune disease. Despite the important role of the Arg131His variant, little is understood about heterozygous genotype effects on global gene expression and cytokine production during an...

Topics

Adolescent
Adult
Aged
Alleles
Antibodies
CD28 Antigens
CD3 Complex
Child
Genotype
Heterozygote
Homozygote
Humans
Interferon-gamma

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Identifiers

PMID: 29977032
DOI: 10.1038/s41435-018-0038-8
PMCID: PMC8026236

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Interleukin-12

Interleukin-2

Leukocytes

Middle Aged

Polymorphism, Genetic