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Article

RUNX1 is required for oncogenic Myb and Myc enhancer activity in T-cell acute lymphoblastic leukemia

8 Aug 2017

Abstract excerpt

Key Points RUNX1 maintains Myb and Myc enhancer activity and is required for leukemogenesis in vivo. RUNX1 inhibition impairs the growth of primary T-ALL patient cells without an effect on normal human hematopoietic cells.

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Identifiers

PMID: 28790107
DOI: 10.1182/blood-2017-03-775536

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