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Article

Distinct gene expression pattern of RUNX1 mutations coordinated by target repression and promoter hypermethylation in acute myeloid leukemia.

Frontiers of medicine - 1 Aug 2022

Li Jingming, Jin Wen, Tan Yun, Wang Beichen, Wang Xiaoling, Zhao Ming, Wang Kankan

Abstract excerpt

Runt-related transcription factor 1 (RUNX1) is an essential regulator of normal hematopoiesis. Its dysfunction, caused by either fusions or mutations, is frequently reported in acute myeloid leukemia (AML). However, RUNX1 mutations have been largely under-explored compared with RUNX1 fusions mainly due to their elusive genetic characteristics. Here, based on 1741 patients with AML, we report a unique expression...

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Share to Core Binding Factor Alpha 2 Subunit
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukemia, Myeloid, Acute

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Share to Promoter Regions, Genetic

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Identifiers

PMID: 34958450
DOI: 10.1007/s11684-020-0815-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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