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Article

Phase separation of SHP2E76K promotes malignant transformation of mesenchymal stem cells by activating mitochondrial complexes.

JCI insight - 7 Mar 2024

Kan Chen, Tan Zhenya, Liu Liwei, Liu Bo, Zhan Li, Zhu Jicheng, Li Xiaofei, Lin Keqiong, Liu Jia, Liu Yakun, Yang Fan, Wong Mandy, Wang Siying, Zheng Hong

Abstract excerpt

Mesenchymal stem cells (MSCs), suffering from diverse gene hits, undergo malignant transformation and aberrant osteochondral differentiation. Src homology region 2-containing protein tyrosine phosphatase 2 (SHP2), a nonreceptor protein tyrosine phosphatase, regulates multicellular differentiation, proliferation, and transformation. However, the role of SHP2 in MSC fate determination remains unclear. Here, we...

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Source

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Identifiers

PMID: 38451719
DOI: 10.1172/jci.insight.170340
PMCID: PMC11141883

Genes

MSC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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