Article
The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo.
Leukemia - 1 Feb 2013
Nabinger S C, Li X J, Ramdas B, He Y, Zhang X, Zeng L, Richine B, Bowling J D, Fukuda S, Goenka S, Liu Z, Feng G-S, Yu M, Sandusky G E, Boswell H S, Zhang Z-Y, Kapur R, Chan R J
Abstract excerpt
Internal tandem duplications (ITDs) in the fms-like tyrosine kinase receptor (FLT3-ITDs) confer a poor prognosis in acute myeloid leukemia (AML). We hypothesized that increased recruitment of the protein tyrosine phosphatase, Shp2, to FLT3-ITDs contributes to FLT3 ligand (FL)-independent hyperproliferation and STAT5 activation. Co-immunoprecipitation demonstrated constitutive association of Shp2 with the...
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