Development of synovial sarcoma organoids exhibiting ferroptosis resistance despite low malic enzyme 1 expression

Abstract excerpt

<title>Abstract</title> <p>Although several studies have investigated synovial sarcoma using established cell lines and mouse models, effective treatments remain limited. We treated five patients with synovial sarcoma at our institute between 2022 and 2023, and resected tumor specimens were cultured using a modified air–liquid interface organoid method. After serial passaging and xenografting into NOD-scid IL2Rgn...

Topics

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• Bone Tumor Diagnosis and Treatments
• CAR-T cell therapy research
• Invertebrate Immune Response Mechanisms
• Oral and Maxillofacial Pathology
• Peptidase Inhibition and Analysis
• Protein Degradation and Inhibitors
• Sarcoma Diagnosis and Treatment
• Virus-based gene therapy research

Identifiers and source

Literature Corpus work

e17b8bef-3d8c-5bcc-9bba-b504a7a90c00

DOI

10.21203/rs.3.rs-6871133/v1