Article

P2RX7 promotes osteosarcoma progression and glucose metabolism by enhancing c-Myc stabilization

2022-11-15

Abstract excerpt

<title>Abstract</title> <p>Background Osteosarcoma is the most common malignant tumor in bone and the prognosis has reached a plateau in the past few decades. Recently, metabolic reprogramming has attracted increasing attention in the research on cancer progression. In our previous study, P2RX7 has been determined as on oncogene in osteosarcoma. However, whether and how P2RX7 promotes osteosarcoma growth and met...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 916886c8-4f89-5a82-8736-4437dde2a6c3
DOI: 10.21203/rs.3.rs-2163991/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

P2RX7 promotes osteosarcoma progression and glucose metabolism by enhancing c-Myc stabilizationDOI 10.21203/rs.3.rs-2163991/v1Read

Cancer Metabostemness and Metabolic Reprogramming via P2X7 ReceptorSemantic proximity Read

In vitro modeling of nutritional and mitochondria-targeted therapies for osteosarcomaSemantic proximity Read

Super-enhancer-driven MLX mediates redox balance maintenance via SLC7A11 in osteosarcomaSemantic proximity Read

Comprehensive Analysis of Metabolism-Related lncRNA Related To The Progression And Prognosis In Osteosarcoma From TCGASemantic proximity Read

Protein synthesis inhibitors stimulate MondoA transcriptional activity by driving an accumulation of glucose 6-phosphateSemantic proximity Read

Deletion of Trp53 and Rb1 in Ctsk‐expressing cells drives osteosarcoma progression by activating glucose metabolism and YAP signalingSemantic proximity Read

Metabolic reprogramming as a novel regulator of skeletal muscle development and regenerationSemantic proximity Read

The P2RX7B splice variant modulates osteosarcoma cell behaviour and metastatic propertiesSemantic proximity Read

Metabolic remodeling during somatic cell reprogramming to induced pluripotent stem cells: involvement of hypoxia-inducible factor 1Semantic proximity Read

The Role and Mechanism of Exosome-Mediated miR-875-3p in Targeting SLC39A14 to Regulate Ferroptosis in Osteosarcoma Proliferation, Migration, and InvasionSemantic proximity Read

CAFs exosomal miR-21-5p suppresses ferroptosis and promotes proliferation and migration in osteosarcomaSemantic proximity Read

Restoring oxidative phosphorylation enhances osteogenesis in mitochondrial DNA translation defective human bone marrow stromal cellsSemantic proximity Read