Article
Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT.
Blood - 27 Sept 2012
Mali Raghuveer Singh, Ma Peilin, Zeng Li-Fan, Martin Holly, Ramdas Baskar, He Yantao, Sims Emily, Nabinger Sarah, Ghosh Joydeep, Sharma Namit, Munugalavadla Veerendra, Chatterjee Anindya, Li Shuo, Sandusky George, Craig Andrew W, Bunting Kevin D, Feng Gen-Sheng, Chan Rebecca J, Zhang Zhong-Yin, Kapur Reuben
Abstract excerpt
Intracellular mechanism(s) that contribute to promiscuous signaling via oncogenic KIT in systemic mastocytosis and acute myelogenous leukemia are poorly understood. We show that SHP2 phosphatase is essential for oncogenic KIT-induced growth and survival in vitro and myeloproliferative disease (MPD) in vivo. Genetic disruption of SHP2 or treatment of oncogene-bearing cells with a novel SHP2 inhibitor alone or in...
Topics
- Animals
- Apoptosis
- Blotting, Western
- Bone Marrow Transplantation
- Cell Proliferation
- Cell Transformation, Neoplastic
- Class Ia Phosphatidylinositol 3-Kinase
- GRB2 Adaptor Protein