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From Stem to Sternum: The Role of Shp2 in the Skeleton.

Calcified tissue international - 1 Apr 2023

Jensen Nathaniel R, Kelly Ryan R, Kelly Kirsten D, Khoo Stephanie K, Sidles Sara J, LaRue Amanda C

Abstract excerpt

Src homology-2 domain-containing phosphatase 2 (SHP2) is a ubiquitously expressed phosphatase that is vital for skeletal development and maintenance of chondrocytes, osteoblasts, and osteoclasts. Study of SHP2 function in small animal models has led to insights in phenotypes observed in SHP2-mutant human disease, such as Noonan syndrome. In recent years, allosteric SHP2 inhibitors have been developed to...

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PMID: 36422682
DOI: 10.1007/s00223-022-01042-3

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