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Article

Immunoglobulin G genetic variation can confound assessment of antibody levels via altered binding to detection reagents

1 Jan 2024

Abstract excerpt

Abstract Objectives Amino acid variations across more than 30 immunoglobulin (Ig) allotypes may introduce structural changes that influence recognition by anti‐Ig detection reagents, consequently confounding interpretation of antibody responses, particularly in genetically diverse cohorts. Here, we assessed a panel of commercial monoclonal anti‐IgG1 clones for capacity to universally recognise two dominant IgG1...

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PMID: 38433763
DOI: 10.1002/cti2.1494

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