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Genetic determinants of IgG antibody response to COVID-19 vaccination

1 Jan 2024

Abstract excerpt

Human humoral immune responses to SARS-CoV-2 vaccines exhibit substantial inter-individual variability and have been linked to vaccine efficacy. To elucidate the underlying mechanism behind this variability, we conducted a genome-wide association study (GWAS) on the anti-spike IgG serostatus of UK Biobank participants who were previously uninfected by SARS-CoV-2 and had received either the first dose (n = 54,066)...

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Identifiers

PMID: 38181733
DOI: 10.1016/j.ajhg.2023.12.005

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