TET CpG sequence-context-specific DNA demethylation shapes progression of IDH-mutant gliomas.

doi:10.1016/j.xcrm.2026.102682

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Article

TET CpG sequence-context-specific DNA demethylation shapes progression of IDH-mutant gliomas.

Cell reports. Medicine - 17 Mar 2026

Hoogstrate Youri, Ghisai Santoesha A, van Hijfte Levi, Head Rania, de Heer Iris, Padovan Marta, de Wit Maurice, Vallentgoed Wies R, Dipasquale Angelo, Wijnenga Maarten M J, Weenink Bas, Luning Rosa, Maas Sybren L N, Brzobohata Adela, Weller Michael, Weiss Tobias, Mair Maximilian J, Berghoff Anna S, Wöhrer Adelheid, Jeltsch Albert, Koekkoek Johan A F, Hazelbag Hans M, Kouwenhoven Mathilde C M, Kim Yongsoo, Westerman Bart A, Ylstra Bauke, Niers Anneke M, Johnson Kevin C, Varn Frederick S, Verhaak Roel G W, Khasraw Mustafa, van den Bent Martin J, Wesseling Pieter, French Pim J

Abstract excerpt

Treatment decisions in IDH-mutant oligodendrogliomas are shaped by tumor aggressiveness, underscoring the need for objective grading of these malignant brain tumors. We collect 302 primary and recurrent resections from oligodendrogliomas and perform Ki-67 staining, proteomics, and DNA methylation profiling. During tumor progression, DNA methylation of oligodendrogliomas changes along a continuum. This continuum...

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Identifiers

PMID: 41850239
DOI: 10.1016/j.xcrm.2026.102682
PMCID: PMC13006442

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