Article
Implication of metabolism in the polarization of tumor-associated-macrophages: the mass spectrometry-based point of view.
Frontiers in immunology - 1 Jan 2023
De Simone Giulia, Soldani Cristiana, Morabito Aurelia, Franceschini Barbara, Ferlan Fabrizio, Costa Guido, Pastorelli Roberta, Donadon Matteo, Brunelli Laura
Abstract excerpt
Tumor-associated macrophages (TAMs) represent one of the main tumor-infiltrating immune cell types and are generally categorized into either of two functionally contrasting subtypes, namely classical activated M1 macrophages and alternatively activated M2 macrophages. TAMs showed different activation states that can be represent by the two extremes of the complex profile of macrophages biology, the M1-like...
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