Article
Metabolic dysfunction and early-onset colorectal cancer - how macrophages build the bridge.
Cancer medicine - 1 Sept 2020
Scheurlen Katharina M, Billeter Adrian T, O'Brien Stephen J, Galandiuk Susan
Abstract excerpt
BACKGROUND: The incidence of colorectal cancer (CRC) among patients <50 years of age has increased dramatically over the last decades. At the same time, the growing proportion of obese children and adolescents and the increasing proportion of young and obese patients with CRC suggests an association between metabolic dysfunction and carcinogenesis. Tumor-associated macrophages (TAMs) are able to orchestrate tumor...
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