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Application of a 3D hydrogel-based model to replace use of animals for passaging patient-derived xenografts

9 May 2023

Abstract excerpt

Purpose: This 3D in vitro cancer model for propagation of patient-derived cells, using a synthetic self-assembling peptide gel, allows the formation of a fully characterised, tailorable tumour microenvironment. Unlike many existing 3D cancer models, the peptide gel is inert, apart from molecules and motifs deliberately added or produced by cells within the model. Methods: Breast cancer patient-derived xenografts...

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PMID: 37808200
DOI: 10.1007/s44164-023-00048-x

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