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Article

Genetic associations with ratios between protein levels detect new pQTLs and reveal protein-protein interactions.

Cell genomics - 13 Mar 2024

Suhre Karsten

Abstract excerpt

Protein quantitative trait loci (pQTLs) are an invaluable source of information for drug target development because they provide genetic evidence to support protein function, suggest relationships between cis- and trans-associated proteins, and link proteins to disease endpoints. Using Olink proteomics data for 1,463 proteins measured in over 54,000 samples of the UK Biobank, we identified 4,248 associations with...

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Identifiers

PMID: 38412862
DOI: 10.1016/j.xgen.2024.100506
PMCID: PMC10943581

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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