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Article

A novel model to study mechanisms of cholestasis in human cholangiocytes reveals a role for the SIPR2 pathway.

Hepatology communications - 1 Mar 2024

Islam Diana, Israr Izza, Taleb Mohamed A B, Rao Aditya, Yosief Robel, Sultana Rukhsar, Sampaziotis Fotios, Tysoe Olivia C, Trauner Michael, Karpen Saul J, Ghanekar Anand, Kamath Binita M

Abstract excerpt

BACKGROUND: Ductular reactivity is central to the pathophysiology of cholangiopathies. Mechanisms underlying the reactive phenotype activation by exogenous inflammatory mediators and bile acids are poorly understood. METHODS: Using human extrahepatic cholangiocyte organoids (ECOs) we developed an injury model emulating the cholestatic microenvironment with exposure to inflammatory mediators and various pathogenic...

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Identifiers

PMID: 38407207
DOI: 10.1097/HC9.0000000000000389
PMCID: PMC10898671

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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