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Article

MicroRNA‐506 promotes primary biliary cholangitis–like features in cholangiocytes and immune activation

18 Sept 2017

Abstract excerpt

Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease associated with autoimmune phenomena targeting intrahepatic bile duct cells (cholangiocytes). Although its etiopathogenesis remains obscure, development of antimitochondrial autoantibodies against pyruvate dehydrogenase complex E2 is a common feature. MicroRNA (miR) dysregulation occurs in liver and immune cells of PBC patients, but its...

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PMID: 28922472
DOI: 10.1002/hep.29533

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