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Article

IL-17 signaling in primary sclerosing cholangitis patient-derived organoids

1 Jun 2024

Abstract excerpt

BACKGROUND: The pathogenesis of primary sclerosing cholangitis (PSC) is unclear, although studies implicate IL-17A as an inflammatory mediator in this disease. However, a direct assessment of IL-17 signaling in PSC cholangiocytes is lacking. In this study, we aimed to investigate and characterize the response of PSC extrahepatic cholangiocyte organoids (ECO) to IL-17A stimulation. METHODS: Cholangiocytes obtained...

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PMID: 38829197
DOI: 10.1097/hc9.0000000000000454

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