Article

IL-17 Signaling in Primary Sclerosing Cholangitis Patient-Derived Organoids

2023-10-16

Abstract excerpt

<title>Abstract</title> <p>The pathogenesis of primary sclerosing cholangitis (PSC) is unclear, although studies implicate IL-17A as an inflammatory mediator in this disease. However, a direct assessment of IL-17 signaling in PSC cholangiocytes is lacking. In this study we aimed to investigate the response of PSC extrahepatic cholangiocyte organoids (ECO) to IL-17A stimulation. Cholangiocytes obtained from PSC an...

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Literature Corpus work: 584f78d5-c2fe-58b5-bca7-4f708c27c5be
DOI: 10.21203/rs.3.rs-3406046/v1

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