Article
Mesoscale DNA feature in antibody-coding sequence facilitates somatic hypermutation.
Cell - 11 May 2023
Wang Yanyan, Zhang Senxin, Yang Xinrui, Hwang Joyce K, Zhan Chuanzong, Lian Chaoyang, Wang Chong, Gui Tuantuan, Wang Binbin, Xie Xia, Dai Pengfei, Zhang Lu, Tian Ying, Zhang Huizhi, Han Chong, Cai Yanni, Hao Qian, Ye Xiaofei, Liu Xiaojing, Liu Jiaquan, Cao Zhiwei, Huang Shaohui, Song Jie, Pan-Hammarström Qiang, Zhao Yaofeng, Alt Frederick W, Zheng Xiaoqi, Da Lin-Tai, Yeap Leng-Siew, Meng Fei-Long
Abstract excerpt
Somatic hypermutation (SHM), initiated by activation-induced cytidine deaminase (AID), generates mutations in the antibody-coding sequence to allow affinity maturation. Why these mutations intrinsically focus on the three nonconsecutive complementarity-determining regions (CDRs) remains enigmatic. Here, we found that predisposition mutagenesis depends on the single-strand (ss) DNA substrate flexibility determined...
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