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Article

Phosphorylation of RyR2 simultaneously expands the dyad and rearranges the tetramers.

The Journal of general physiology - 1 Apr 2024

Asghari Parisa, Scriven David R L, Shahrasebi Saba, Valdivia Hector H, Alsina Katherina M, Valdivia Carmen R, Navarro-Garcia J Alberto, Wehrens Xander H T, Moore Edwin D W

Abstract excerpt

We have previously demonstrated that type II ryanodine receptors (RyR2) tetramers can be rapidly rearranged in response to a phosphorylation cocktail. The cocktail modified downstream targets indiscriminately, making it impossible to determine whether phosphorylation of RyR2 was an essential element of the response. Here, we used the β-agonist isoproterenol and mice homozygous for one of the following clinically...

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Identifiers

PMID: 38385988
DOI: 10.1085/jgp.202213108
PMCID: PMC10883851

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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