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Article

Severe acute respiratory syndrome coronavirus nsp1 suppresses host gene expression, including that of type I interferon, in infected cells.

Journal of virology - 1 May 2008

Narayanan Krishna, Huang Cheng, Lokugamage Kumari, Kamitani Wataru, Ikegami Tetsuro, Tseng Chien-Te K, Makino Shinji

Abstract excerpt

The severe acute respiratory syndrome coronavirus (SARS-CoV) nsp1 protein has unique biological functions that have not been described in the viral proteins of any RNA viruses; expressed SARS-CoV nsp1 protein has been found to suppress host gene expression by promoting host mRNA degradation and inhibiting translation. We generated an nsp1 mutant (nsp1-mt) that neither promoted host mRNA degradation nor suppressed...

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Source

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Identifiers

PMID: 18305050
DOI: 10.1128/JVI.02472-07
PMCID: PMC2293030

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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