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The impact of Coronavirus Nsp1 on host mRNA degradation is independent of its role in translation inhibition

29 Mar 2025

Abstract excerpt

When host cells are infected with coronaviruses, the first viral protein produced is non-structural protein 1 (Nsp1). This protein inhibits host protein synthesis and induces host mRNA degradation to enhance viral proliferation. Despite its critical role, the mechanism by which Nsp1 mediates cellular mRNA degradation remains unclear. In this study, we use cell-free translation to address how host mRNA stability...

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PMID: 40153437
DOI: 10.1016/j.celrep.2025.115488

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